An Improved Delta-Centralization Method for Population Stratification
نویسندگان
چکیده
منابع مشابه
An Improved Delta-Centralization Method for Population Stratification
Dadd et al. [Hum Hered 2010; 69: 285–294] recently criticized our delta-centralization (DC) method of controlling for population stratification (PS) and concluded that DC does not work. To explore our method, the authors simulated data under the Balding-Nichols (BN) model, which is more general than the model we had used in our simulations. They determined that the DC method underestimated the ...
متن کاملAn improved delta-centralization method for population stratification.
Dadd et al. [Hum Hered 2010;69:285-294] recently criticized our delta-centralization (DC) method of controlling for population stratification (PS) and concluded that DC does not work. To explore our method, the authors simulated data under the Balding-Nichols (BN) model, which is more general than the model we had used in our simulations. They determined that the DC method underestimated the PS...
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OBJECTIVE To investigate the validity of simulations and assumptions used to underpin the delta-centralization (DC) method for correcting for population stratification in genetic association studies; to assess the effectiveness of DC compared to genomic control (GC) under valid simulation conditions; and to highlight other studies employing similarly flawed simulations. METHODS DC and GC use ...
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ژورنال
عنوان ژورنال: Human Heredity
سال: 2011
ISSN: 1423-0062,0001-5652
DOI: 10.1159/000327728